03053nab a22003974a 4500003000400000005001700004008004100021022006100062040003800123041000800161046003800169100002100207100002200228245013200250246009300382260007500475270002400550300001500574338001200589362002600601490008800627500012200715504002700837520002700864520113500891650002802026650005202054650003802106650003002144650001902174651001402193710011902207773017702326852003402503856011802537OSt20260715141146.0260714t2 2 v ||||||||||a00| 0 s d 2Boletín de Malariología y Salud Ambientala1690-4648 aSAIAE Dr. Arnoldo Gabaldon VE48.1 aspa jSAIAE Dr. Arnoldo Gabaldon VE48.1 aDe Jesús, Rosa aTorres, Elizabeth aEvaluación de factores de reproducción para detectar posible contaminación genética en cepas consanguíneas de ratones aEvaluation of reproductive parameters for genetic contamination in mouse strains inbred. aMaracaybS.A. Instituto de Altos Estudios "Dr. Arnoldo Gabaldon"c2006 bMaracaycAraguadVE a7 p.btab. aDigital aAgosto-Diciembre 2006 aBoletín de Malariología y Salud AmbientalvXLVI (2) 2006, 161-167 x1690 - 4648 aConsentimiento del autor para la reproducción total o parcial de su trabajo; siempre y cuando se indiquen la fuente aIncluye 19 referencias aIncluye 19 referencias a Inbred strains of mice are used in biomedical research because characteristics such as homozygosis and isogenicity which result from mated brother and sister, descendants of an original pair for more than twenty consecutive generations. The genome integrity of these strains can be altered by genetic contamination, mutations and genetic drift. Genetic contamination is the most common problem affecting the genome of the animals of production colonies. The evaluation of some production factors can be used as warning of genetic contamination. If, after these production factors have been evaluated, it seems that there is genome alteration in the strain, it is advisable to apply any specific laboratory technique. In the present study some of the production parameters of the colonies of inbred strains of mice bred in Venezuela were evaluated; these are: conditions of the animals quarters, reproductive zootechnic parameters; number of offspring per litter. Results of this evaluation led to recommending the analysis of some molecular markers as microsatellites that are the most appropriate technique for this purpose(AU)  a RATONES ENDOGÁMICOS  aRATONES ENDOGÁMICOS/crecimiento y desarrollo  aRATONES ENDOGÁMICOS/genética  aESTANDARES DE REFERENCIA  aCONSANGUINIDAD aVENEZUELA aMinisterio del Poder Popular para la SaludbServicio Autónomo Instituto de Altos Estudios "Dr. Arnoldo Gabaldon"0 010569aMinisterio del Poder Popular para la SaluddMaracay S.A. IAE “Dr. Arnoldo Gabaldon” 2006tBoletín de Malariología y Salud Ambiental Vol. 46-2 2006x1690-4648 aBMSA Vol. 46 (2) 2006 Digital uhttps://cainfo.iaes.edu.ve/cgi-bin/koha/opac-retrieve-file.pl?id=c6cca2d303bed4f7339e857c5241c8fdyTexto Completo