03097nab a22004214a 4500 OSt 20260715141146.0 260714t2 2 v ||||||||||a00| 0 s d Boletín de Malariología y Salud Ambiental 1690-4648 SAIAE Dr. Arnoldo Gabaldon VE48.1 spa SAIAE Dr. Arnoldo Gabaldon VE48.1 De Jesús, Rosa Torres, Elizabeth Evaluación de factores de reproducción para detectar posible contaminación genética en cepas consanguíneas de ratones Evaluation of reproductive parameters for genetic contamination in mouse strains inbred. Maracay S.A. Instituto de Altos Estudios "Dr. Arnoldo Gabaldon" 2006 Maracay Aragua VE 7 p. tab. Digital Agosto-Diciembre 2006 Boletín de Malariología y Salud Ambiental XLVI (2) 2006, 161-167 1690 - 4648 Consentimiento del autor para la reproducción total o parcial de su trabajo; siempre y cuando se indiquen la fuente Incluye 19 referencias Incluye 19 referencias Inbred strains of mice are used in biomedical research because characteristics such as homozygosis and isogenicity which result from mated brother and sister, descendants of an original pair for more than twenty consecutive generations. The genome integrity of these strains can be altered by genetic contamination, mutations and genetic drift. Genetic contamination is the most common problem affecting the genome of the animals of production colonies. The evaluation of some production factors can be used as warning of genetic contamination. If, after these production factors have been evaluated, it seems that there is genome alteration in the strain, it is advisable to apply any specific laboratory technique. In the present study some of the production parameters of the colonies of inbred strains of mice bred in Venezuela were evaluated; these are: conditions of the animals quarters, reproductive zootechnic parameters; number of offspring per litter. Results of this evaluation led to recommending the analysis of some molecular markers as microsatellites that are the most appropriate technique for this purpose(AU) RATONES ENDOGÁMICOS RATONES ENDOGÁMICOS/crecimiento y desarrollo RATONES ENDOGÁMICOS/genética ESTANDARES DE REFERENCIA CONSANGUINIDAD VENEZUELA Ministerio del Poder Popular para la Salud Servicio Autónomo Instituto de Altos Estudios "Dr. Arnoldo Gabaldon" 10569 3810 Ministerio del Poder Popular para la Salud Maracay S.A. IAE “Dr. Arnoldo Gabaldon” 2006 Boletín de Malariología y Salud Ambiental Vol. 46-2 2006 1690-4648 BMSA Vol. 46 (2) 2006 Digital https://cainfo.iaes.edu.ve/cgi-bin/koha/opac-retrieve-file.pl?id=c6cca2d303bed4f7339e857c5241c8fd Texto Completo AC 0 ddc 10699 10699