TY  - SER
AU  - De Jesús, Rosa
AU  - Torres, Elizabeth
ED  - Ministerio del Poder Popular para la Salud
TI  - Evaluación de factores de reproducción para detectar posible contaminación genética en cepas consanguíneas de ratones
T2  - Boletín de Malariología y Salud Ambiental
SN  - 1690-4648
PY  - 2006///
CY  - Maracay
PB  - S.A. Instituto de Altos Estudios "Dr. Arnoldo Gabaldon"
KW  -  RATONES ENDOGÁMICOS
KW  - RATONES ENDOGÁMICOS/crecimiento y desarrollo
KW  - RATONES ENDOGÁMICOS/genética
KW  - ESTANDARES DE REFERENCIA
KW  - CONSANGUINIDAD
KW  - VENEZUELA
N1  - Consentimiento del autor para la reproducción total o parcial de su trabajo; siempre y cuando se indiquen la fuente; Incluye 19 referencias
N2  - Incluye 19 referencias;  Inbred strains of mice are used in biomedical research because characteristics such as homozygosis and isogenicity which result from mated brother and sister, descendants of an original pair for more than twenty consecutive generations. The genome integrity of these strains can be altered by genetic contamination, mutations and genetic drift. Genetic contamination is the most common problem affecting the genome of the animals of production colonies. The evaluation of some production factors can be used as warning of genetic contamination. If, after these production factors have been evaluated, it seems that there is genome alteration in the strain, it is advisable to apply any specific laboratory technique. In the present study some of the production parameters of the colonies of inbred strains of mice bred in Venezuela were evaluated; these are: conditions of the animals quarters, reproductive zootechnic parameters; number of offspring per litter. Results of this evaluation led to recommending the analysis of some molecular markers as microsatellites that are the most appropriate technique for this purpose(AU)
UR  - https://cainfo.iaes.edu.ve/cgi-bin/koha/opac-retrieve-file.pl?id=c6cca2d303bed4f7339e857c5241c8fd
ER  -